SECTION I Basics of Laboratory Medicine

1 Clinical Chemistry and Molecular Diagnostics

2 Statistical Methodologies in Laboratory Medicine: Analytical and Clinical Evaluation of Laboratory

Tests

3 Quality Management in the Medical Laboratory*

4 Specimen Collection and Processing

5 Preanalytical Variation and Preexamination Processes

6 Quality Control of the Analytical Examination Process

7 Biological Variation

8 Establishment and Use of Reference Intervals

9 Evidence-Based Laboratory Medicine*

10 Biobanking*

11 Laboratory Support of Pharmaceutical, In Vitro Diagnostics, and Epidemiologic Studies*

SECTION II Analytical Techniques and Applications  

12 Principles of Basic Techniques and Laboratory Safety*

13 Optical Techniques

14 Electrochemistry and Chemical Sensors

15 Electrophoresis

16 Chromatography

17 Mass Spectrometry

18 Sample Preparation for Mass Spectrometry Applications*

19 Mass Spectrometry Applications in Infectious Disease and Pathogens Identification*

20 Development and Validation of Small Molecule Analytes by Liquid Chromatography-Tandem Mass

Spectrometry*

21 Proteomics*

22 Enzyme and Rate Analysis

23 Immunochemical Techniques

24 Microfabrication and Microfluidics and Their Application in Clinical Diagnostics*

25 Cytometry*

26 Automation in the Clinical Laboratory*

27 Point-of-Care Testing*

SECTION III Analytes  

28 Amino Acids, Peptides, and Proteins

29 Serum Enzymes

30 Enzymes of the Red Blood Cell*

31 Tumor Markers

32 Kidney Function Tests

33 Carbohydrates

34 Lipids, Lipoproteins, Apolipoproteins, and Other Cardiovascular Risk Factors

35 Electrolytes and Blood Gases

36 Hormones

37 Vitamins and Trace Elements

38 Hemoglobin, Iron, Bilirubin

39 Porphyrins and the Porphyrias

40 Therapeutic Drugs and Their Management

41 Clinical Toxicology

42 Toxic Elements

43 Body Fluids*

SECTION IV Molecular Diagnostics  

44 Principles of Molecular Biology

45 Genomes and Variants

46 Nucleic Acid Isolation*

47 Nucleic Acid Techniques

48 Molecular Microbiology

49 Genetics, 1025

50 Solid Tumor Genomics

51 Genetic Aspects of Hematopoietic Malignancies

52 Circulating Tumor Cells and Circulating Tumor DNA

53 Circulating Nucleic Acids for Prenatal Diagnostics

54 Pharmacogenetics*

55 Identity Testing*

SECTION V Pathophysiology

56 Nutrition: Laboratory and Clinical Aspects*

57 Diabetes Mellitus

58 Cardiac Function

59 Kidney Disease

60 Disorders of Water, Electrolytes, and Acid–Base Metabolism

61 Liver Disease

62 Gastric, Pancreatic, and Intestinal Function

63 Monoamine-Producing Tumors*

64 Bone and Mineral Metabolism

65 Pituitary Function and Pathophysiology

66 Adrenal Cortex

67 Thyroid Disorders

68 Reproductive Endocrinology and Related Disorders

69 Pregnancy and Its Disorders

70 Newborn Screening and Inborn Errors of Metabolism

SECTION VI Hematology and Coagulation  

71 Hemostasis*

Russell A. Higgins, Steve Kitchen, and Dong Chen

72 Red Blood Cell Morphology and Indices With Clinical Chemistry Interface*

73 Automated Hematology*

SECTION VII Microbiology  

74 Bacteriology*

75 Antimicrobial Susceptibility Testing*

76 Mycobacteriology*

77 Mycology*

78 Parasitology*

79 Virology*

SECTION VIII Transfusion Medicine  

80 Blood Groups, Pretransfusion Testing, and Red Blood Cell Transfusion*

81 Blood Components, Blood Donor Screening, and Transfusion Reactions*

Appendix Reference Information for the Clinical Laboratory